Science, Space and Technology News 2024
Researchers have found that studying proteins at body temperature reveals new drug binding sites, potentially revolutionizing drug design by providing more physiologically relevant insights into protein structure. Credit: SciTechDaily.com
Proteins generally are investigated at low temperatures to ensure their stability. However, the new study demonstrates that certain proteins are highly sensitive to temperature and change their shape when viewed at body temperature. Although it is well known that temperature affects molecular function in the body, studying proteins at physiological temperature has been technologically challenging. Today’s study by the Du and Lü laboratories details how they overcame these issues and provides scientists a roadmap for doing so in their own experiments.
To visualize TRPM4 at body temperature, the team leveraged VAI’s powerful suite of cryo-electron microscopes , which allow scientists to flash freeze proteins and assemble detailed images of their structures. Rather than using a low-temperature sample, Postdoctoral Fellow Jinhong Hu, Ph.D., and colleagues in the Du and Lü laboratories heated the sample to body temperature before flash freezing it.
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