The largest genetic study on heart arrhythmia to date, led by Kazuo Miyazawa and Kaoru Ito at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan, has resulted in the discovery of multiple genes and specific genetic variations linked to atrial fibrillation. The study, recently publis
Heart arrhythmia, also known as an irregular heartbeat, is a condition where the heart beats too quickly, too slowly, or with an irregular pattern. This can cause symptoms such as palpitations, dizziness, fainting, and shortness of breath. In some cases, heart arrhythmias can also increase the risk of more serious conditions, such as stroke or heart failure.
A subsequent cross-ancestry meta-analysis of over 1.2 million people—the same Japanese population along with those from two large European studies—overall yielded 150 critical genetic loci, including 35 that were new. Further analysis found over 130 genes associated with these loci. The likelihood that variations in one or several of these genes leads to atrial fibrillation is therefore high.
“Until now, which genes and how their transcriptional regulation is involved in the pathophysiology of atrial fibrillation was not very clear,” says Kazuo Miyazawa, first author of the study. “In this study, we discovered a key mechanism by integrating genomic data with epigenomic and transcriptomic data.”
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