CHICAGO (REUTERS) - High-profile Covid-19 vaccines developed in Russia and China share a potential shortcoming: They are based on a common cold virus that many people have been exposed to, potentially limiting their effectiveness, some experts say.. Read more at straitstimes.com.
CHICAGO - High-profile Covid-19 vaccines developed in Russia and China share a potential shortcoming: They are based on a common cold virus that many people have been exposed to, potentially limiting their effectiveness, some experts say.
A vaccine developed by Moscow's Gamaleya Institute, approved in Russia earlier this month despite limited testing, is based on Ad5 and a second less common adenovirus. Researchers have experimented with Ad5-based vaccines against a variety of infections for decades, but none are widely used. They employ harmless viruses as"vectors" to ferry genes from the target virus - in this case the coronavirus - into human cells, prompting an immune response to fight the actual virus.
"I think they will get good immunity in people that don't have antibodies to the vaccine, but a lot of people do," said Dr Hildegund Ertl, director of the Wistar Institute Vaccine Centre in Philadelphia. "I would be worried about the use of those vaccines in any country or any population that was at risk of HIV, and I put our country as one of them," said Dr Larry Corey, co-leader of the US Coronavirus Vaccine Prevention Network, who was a lead researcher on the Merck trial.
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