SINGAPORE: A local study has unveiled a promising treatment approach for Non-Small Cell Lung Cancer , the most common lung cancer subtype among non-smokers and one of the leading global causes of canc
er-related deaths.
A team led by Assistant Professor Minh Le of the Institute for Digital Medicine and Department of Pharmacology at the National University of Singapore’s Yong Loo Lin School of Medicine has demonstrated that extracellular vesicles from human red blood cells could be repurposed to deliver anti-cancer drugs directly to lung cancer cells.
The current standard treatment, tyrosine kinase inhibitors , targets the mutant EGFR protein but often encounters resistance due to further mutations. Published in eBioMedicine, the study emphasizes the ASOs’ advantage in targeting specific genes. This adaptability is key for NSCLC, which frequently develops resistance to broad-spectrum therapies like TKIs.To counter this, the researchers used EVs from red blood cells to encase and transport ASOs, preventing degradation and enabling direct delivery to tumour sites.
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