Nature research paper: Structure of the MRAS-SHOC2-PP1C phosphatase complex
. However, our mechanistic understanding of how RAS signals through RAF is still incomplete. While studies revealed snapshots for autoinhibited and active RAF–MEK1–14-3-3 complexes, the intermediate steps leading to RAF activation remain unclear. The MRAS-
and PP1C are mutated in Rasopathies, developmental syndromes caused by aberrant MAPK pathway activation. Despite its importance, structural understanding of the -PP1C complex.
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