Researchers revealed the importance of the transmission of epigenetic information through cell division for embryonic stem cells functionality. This has broad implications for aging, cancer, and regenerative medicine.
each type of cell expresses and has the potential to communicate this information to its daughter cells.
"Understanding the layers which control epigenetic memory could be a key to aging and cancer avoidance as well as facilitating more efficient cellular reprogramming and trans-differentiation for applications regenerative medicine," says Joshua Brickman, Professor at Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW Copenhagen.
"By using this information, we were able to manipulate the machinery to create mouse embryotic stem cells, where one daughter DNA strand lacks the transmitted histones with the memory signal while the other gets it all," says postdoc at Novo Nordisk Foundation for Protein Research Alva Biran and co first author of the study.
, which the investigator found to enable the balanced inheritance of functional properties associated with cell identity.
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