Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of mortality and morbidity around the globe. Because cardiac tissue possesses very limited regeneration potential, use of a potent small molecule, inhibitor Wnt production-4 (IWP-4) for stem cell differentiation into cardiomyocytes could be a promising approach for cardiac regeneration.
Wnt pathway inhibitors may help stem cells in their fate determination toward cardiomyogenic lineage and provide better homing and survival of cells in vivo. Mesenchymal stem cells derived from the human umbilical cord have the potential to regenerate
The MI rat model was developed, and IWP-4 treated as well as untreated MSCs were implanted in the MI model. Then the cardiac function was analyzed via echocardiography. MSCs were labeled with 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate dye for tracking, while the regeneration of infarcted myocardium was examined by histology and immunohistochemistry.
Treatment of MSCs with IWP-4 inhibits Wnt pathway and promotes cardiac differentiation. These pre-conditioned MSCs transplanted in vivo improved
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