Meet Grady, a spiky-haired miracle baby who could help children with cancer grow up to become parents.
Pitt researchers Kyle Orwig and Adetunji Fayomi discuss their research on fertility preservation.
Scientists are optimistic that the same approach could one day help young boys who undergo aggressive cancer treatments become fathers as well. When an adult man is diagnosed with cancer, he can freeze his sperm before starting chemotherapy or radiation treatment and use it later in standard fertility treatments. But patients who have not yet reached puberty don't have that option — they aren't yet producing sperm.
In order to judge the performance of the frozen tissue samples, the researchers also removed the remaining testis from the five macaques and implanted fresh testicular tissue alongside the preserved samples. The underside of the skin has lots of tiny blood vessels, and researchers suspect that the injury caused by incisions and suturing needles may have enhanced sperm development by stimulating healing and prompting blood vessels to reach out to the grafts.
Sperm from frozen, thawed and grafted testicular tissue is injected into the egg of a rhesus macaque in a microscopic image.
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