This article talks about achieving optimal uniformity and flexibility with tablet coating.
Sponsored Content by L.B. Bohle Maschinen und Verfahren GmbHReviewed by Olivia FrostJul 30 2024 Tablets are the most used oral dose type in the pharmaceutical sector. They have numerous benefits, the most important of which are their capacity to precisely manage dosage and the great stability of active substances.
This covers combination goods and the use of two incompatible active substances in the same dosage form. Furthermore, multiple release profiles of the same active component can be blended. In this example, the slow-release component is located in the core, whereas the fast-release initial dose is found in the tablet coating.Formulation procedures can include up to four film kinds, leading to extended processing times.
The mixing spirals ensure that the tablet bed is continuously and gently mixed. Homogeneous mixing occurs within minutes and is maintained throughout the operation. The flat tablet bed lowers the melt pressure in the tablet bed. L.B. Bohle provides various methods for changing the nozzle bed distance, spray angle, and atomization pressure. Typically, the suspension mass of film-coated tablets ranges from 5 to 15% of the core mass.
There is no heating of the coater's perimeter or housing. Optimal airflow produces a smooth spray pattern, reducing spray drying. The supply air stream does not touch spray nozzles and stays cool during the spraying procedure. This reduces spray drying effects, resulting in >97% or greater coating uniformity.
The necessity of covering small quantities is steadily increasing. Significant flexibility in production equipment is needed in addition to existing laboratory coaters. The BFC tablet coater provides maximum versatility, allowing 10 to 100% batch sizes. Safety concerns have also been considered. Inflatable seals are now standard. The fully automatic sample and loading of tablets with the door closed improves operator safety.
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