A group of researchers at the Technical University of Munich (TUM) has developed the world's first microrobot ('microbot') capable of navigating within groups of cells and stimulating individual cells. Berna Özkale Edelmann, a professor of Nano- and Microrobotics, sees potential for new treatments of human diseases. The research is published in the journal Advanced Healthcare Materials.
were invented by Prof. Berna Özkale Edelmann. To be exact, the bioengineer and director of the Microrobotic Bioengineering Lab has worked with her team of researchers to develop a technological platform for the large-scale production of these vehicles. They are currently being used in vitro, outside the human body.The TACSI microbots differ from classical humanoid robots or robotic arms as seen in factories.
A fluorescent dye: in this case the orange rhodamine B dye is used that loses color intensity with increasing temperature. This makes theGold nanorods: the 25–90 nanometer precious metal rods have the property of heating rapidly when bombarded with. It takes only a few microseconds to raise the temperature of the robot by 5°C. The nanorods can be heated to 60°C.
"This makes it possible to make up to 10,000 microbots in a single production run," explains Philipp Harder, a member of the research team.Small temperature changes are sometimes enough to influence cell processes."When the skin is injured, for example through a cut, the body temperature rises slightly, causing the immune system to be activated," explains Prof. Özkale Edelmann.
She wants to learn more about whether this"thermal stimulation" can be used to heal wounds. There is also a lack of research on whether cancer cells become more aggressive when stimulated. Current studies show that cancer cells die off at high temperatures . This effect can also be used to treat heart arrhythmia and depression.Researchers on Prof. Özkale Edelmann's team used kidney cells to demonstrate that cellular ion channels can be influenced.
"Using this concrete example, we showed that heat causes changes in the cell, even with slight temperature increases," says Prof. Özkale Edelmann. She hopes that further research will point the way to new treatments—for example by making it possible to channel drugs into individual cells.Philipp Harder et al, A Laser‐Driven Microrobot for Thermal Stimulation of Single Cells,
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