The “Thunder God Vine” – An Herbal Compound To Help Fight Arthritis — A team of researchers at O |
It’s universally understood that having a robust immune system is beneficial. However, there are instances where the immune system malfunctions and begins to assault one’s own body. This phenomenon, known as autoimmunity, is responsible for a range of disorders, including rheumatoid arthritis, Crohn’s disease, type 1 diabetes, and celiac disease. To combat these conditions, it’s imperative to uncover the underlying mechanisms that trigger their development.
“We had previously shown that the COMMD3/8 complex potentiates the humoral immune response, yet its role in autoimmune diseases remained unclear,” says Kazuhiro Suzuki, senior author. The team generated a mouse model in which the expression of COMMD3 can be switched off. “Deleting COMMD3 results in the degradation of COMMD8 and, consequently, the disappearance of the COMMD3/8 complex,” explains Taiichiro Shirai, lead author of the study.
Effects of COMMD3/8 complex deficiency and celastrol treatment on the disease progression in a mouse model of rheumatoid arthritis. Credit: 2023 Shirai et al., Science Immunology
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