It involves genetically engineering the body’s disease-fighting T-cells to make them seek out and destroy cancer cells. Read more at straitstimes.com.
WASHINGTON – A treatment that involves genetically modifying the body’s own immune cells has been found to cut the risk of disease progression by 74 per cent in people with a rare type of blood cancer, results showed on Monday.
Ciltacabtagene autoleucel “delivers remarkably effective outcomes compared to patients’ current options” and “can be used safely earlier in the treatment phase”, added Dr Odejide, an expert who was not part of the research. In the new clinical trial, half the patients were randomly assigned ciltacabtagene autoleucel, while the other half received a cocktail of drugs that represents the current standard of care, including chemotherapy and steroids.
CAR T-cell therapy involves removing the patient’s disease-fighting T-cells, and genetically engineering them in a lab so they have specific proteins known as receptors that, once returned to the body, will seek out and destroy cancer cells.Nearly all the patients in both groups experienced severe to life-threatening adverse events, including infections and low blood cell counts.
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