UC San Diego joined a Phase II clinical trial to evaluate additional COVID-19 booster shots to see if different vaccine regimens can broaden immune responses in adults, it was announced Wednesday.
The study, known as the COVID-19 Variant Immunologic Landscape trial, is sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.
"The emergence of SARS-CoV-2 variants has challenged the efficacy of available preventive vaccines," said Dr. Susan Little, professor of medicine at the UCSD School of Medicine and principal investigator of the UCSD trial site."It's clear that we need to learn more about how we might adapt vaccines to match circulating variants and expand and optimize immune coverage to existing and emerging variants.
UCSD is one of 24 academic medical centers around the country enrolling 600 participants in the study. Adults 18 years and older who have already received an FDA-authorized primary COVID-19 vaccination series and a booster shot and are in generally good health may be eligible. Participants are randomly assigned to one of six vaccine regimens.
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