The mechanism extends the life of the immune system. A multinational team headed by University College London scientists has discovered a new mechanism that slows down and maybe even prevents the normal aging of immune cells, one of the nine 'hallmarks of aging.' The discovery in-vitro (cells)
The discovery in-vitro and validated in mice was “unexpected,” according to the researchers, who believe harnessing the mechanism might extend the life of the immune system, enabling people to live healthier and longer lives, and would also have therapeutic use for diseases such as cancer and dementia. Their findings were recently published in the journalExplaining the study, lead author, Dr.
T cells , like other cells, have telomeres that shorten with each cell division . When telomeres reach a critical length, the cell stops dividing and enters senescence, which is the process of being disposed of by the immune system or persisting in an altered, dysfunctional condition. The telomere transfer reaction extended certain telomeres about 30 times more than the extension exerted by telomerase. Telomerase is the single DNA synthesizing enzyme that is devoted to telomere maintenance in stem cells, cells of the immune systems, and found in fetal tissue, reproductive cells, and sperm. However, it does not provide this function in other cells, leading to telomere attrition.
The researchers discovered that the purified extracellular vesicle preparations may be administered alone or in combination with a vaccine and this extended durative immune protection that, in principle, may avoid the need for revaccination.
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