In lung cancer diagnosis and treatment, genetic testing plays an important role in identifying specific mutations in lung cells.
Lung cancer, which occurs when cells in the lung tissue grow abnormally, is the third most frequent cancer in men and women here, according to theIn Singapore, non-small cell lung cancer makes up over 85 per cent of all lung cancer cases, said Dr Daniel Chan Boon Yeow, senior consultant medical oncologist at Icon Cancer Centre.Ms Lim Mei Fong, a patient with non-small cell lung cancer with EGFR Exon 20 insertion mutation, shares her journey with the condition.
“When a mutation happens in the EGFR gene, it produces an abnormal protein and tells the cell to keep growing even without any external stimulus. This leads to cancer, which is defined as uncontrolled cell growth,” Dr Chan explained. Exposure to increasing concentrations of airborne particulate matter – especially particles found in vehicle exhaust and industrial smoke – has been linked to an elevated risk for non-small cell lung cancer with EGFR mutations, according to“The exact cause of these gene mutations is uncertain, but pollution from tiny particulate matter, such as PM2.
The type of test carried out depends on the hospital, and the turnaround time for results may range from three to 10 days, said Dr Chan. “The standard of care for newly diagnosed patients with this particular EGFR mutation is still chemotherapy. However, due to the aggressiveness of the disease, patients usually eventually require further treatment after several cycles of chemotherapy,” he said.Living with lung cancer can be daunting and overwhelming, Dr Chan added, which is why it is important to have a good support system.
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