By combining neuroscience with molecular biology, scientists have discovered that a well-known gene works to withstand psychiatric stress. Researchers have found that Tob, a well-known gene, plays a significant role in reducing depression, fear, and anxiety. This conclusion was reached after
Scientists discovered a gene that plays an important role in reducing depression, fear, and anxiety.
They also discovered that the Tob gene within the hippocampus was important for reducing fear and depression, but not anxiety. That seemed to be controlled by another part of the brain. Tob deletion induces fear and depression-like behaviors. This can be explained by the altered functional connectivity between the hippocampus and the pre-frontal cortex. The neurons in the hippocampus showed increased excitation and decreased inhibition. There were also impacts on other genes and proteins. Credit: OIST
An MRI of the hippocampus and the pre-frontal cortex when the Tob gene was removed. This MRI allowed the researchers to determine that the connectivity between the hippocampus and the pre-frontal cortex had been altered. The image is from the press release “Jumping gene found to be strongly linked to depression, fear, and anxiety.” Credit: OIST
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