Bone marrow cells in the skull have a distinct response to disease, and scientists say this means the skull could be a useful way to watch and potentially treat inflammation in the brain.
is the process of treating biological tissues to make them transparent. In this context, the process allowed light to pass through for microscopic examination of brain tissue and the skull.
The researchers observed cellular architecture of the skull-meninges connections that extend closer to the brain's surface than was previously believed, often penetrating that outermost and toughest meninges membrane, the dura mater. "These findings carry profound implications, suggesting a far more complex connection between the skull and the brain than previously believed"frameborder="0″ allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen>, and the brain, finding different bones have different molecular profiles, with unique immune cells detected in the skull.
Protein analysis of human postmortem skull, spine, and pelvic bone samples once again uncovered the skull's unique molecular profile. The , which forms part of the top of the skull, had the most differentially expressed genes and cellular receptors, mostly related to migration and inflammation.cells, a type of white blood cell that plays a crucial role in the body's immune defense.
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