SINGAPORE: A study by researchers at Duke-NUS Medical School has uncovered the pivotal role of natural killer T cells in shaping the immune response to dengue infections.
The findings, which could offer new strategies for reducing the severity of subsequent dengue infections, highlight how these cells influence whether the body produces protective or harmful antibodies after an initial infection.
A second infection with a different serotype is often linked to more severe illness, a phenomenon known as antibody-dependent enhancement. NKT cells also create a supportive environment in nearby lymph nodes, boosting the immune system’s ability to produce these protective antibodies.3 dead, 2,000 affected by dengue since January, Minister says community must work together towards prevention
Patients with higher levels of these Th1 responses were shown to have better outcomes during primary dengue infections. However, the study also highlighted the risks associated with secondary infections.
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