Expert Explainer: What to Know About Coronavirus Mutations

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Expert Explainer: What to Know About Coronavirus Mutations
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A conversation with Dr. Harm van Bakel, a geneticist at the Icahn School of Medicine

Photo: Apu Gomes/AFP via Getty Images By studying the SARS-CoV-2 genome, researchers have been able to map the coronavirus’s spread around the world from its emergence in China late in 2019. A recent analysis done in China estimates there are now more than 30 strains of the virus spread out across the globe; in New York, a team of researchers at Mount Sinai traced the strain responsible for most of the city’s infections to Europe. Intelligencer spoke with Dr.

The pattern of those changes tells us something about the lineage of the virus. If a mistake is made early, it will be seen in all of the progeny. If a mistake is made later, it will only show up in some of it. By looking at the rate of the change of the virus, we can time some of those changes during the spread of the virus across the world.This is still subject to study, but roughly there is one letter change every two weeks.Most of the changes will be neutral.

What’s the relationship between your work and the work being done by researchers who are trying to develop a vaccine? Our work has really been focused on the strains here in New York and how the virus got to the city. We haven’t really looked at the origins. There are other groups who have done surveillance in animal populations, bat populations, pangolin populations, who are going to be more suited to make determinations on that.

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