Nature research paper: Prefrontal feature representations drive memory recall
a, Schematic of retrograde tracing from dHPC by injecting rgAAV-CAG-tdT in CA1 & CA3. Detection of retrogradely labeled tdT neurons together with nuclei stained with DAPI from coronal sections at 10x; insets show zoom at 40x; CLA: claustrum, MS: Medial septum; LSr: Lateral Septum, AC: Anterior Cingulate, TH – Thalamus; HY/fx: Hypothalamus/fornix, BLA: Basolateral Amygdala, LEC: Lateral Entorhinal Cortex b, Schematic and histology for inhibition imaging.
d, Fraction of CA1 neurons that are context selective is similar across cohorts e-f, Mean ensemble onset activity of CA1 neurons across both AC st-GtACR and LEC st-GtACR cohorts during light-off trials is similar across cohorts for both context-selective neurons and non-context selective neurons g, Mean onset activity in CA1 during light off and light on trials in context selective ensemble and non-context ensemble for LEC inhibition cohort, signifies widespread inhibition of neurons in CA1 .
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